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NGF IN COMPLEX WITH DOMAIN 5 OF THE TRKA RECEPTOR

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Wiesmann, C., Ultsch, M.H., Bass, S.H., and de Vos, A.M., in 1999 in a paper entitled "Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (NERVE GROWTH FACTOR) and PROTEIN (TRKA RECEPTOR).

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
V PROTEIN (NERVE GROWTH FACTOR) P01138 (122-241) (NGF_HUMAN)search Homo sapienssearch < 90% 120 90%
W PROTEIN (NERVE GROWTH FACTOR) P01138 (122-241) (NGF_HUMAN)search Homo sapienssearch < 90% 120 90%
X PROTEIN (TRKA RECEPTOR) P04629 (282-382) (NTRK1_HUMAN)search Homo sapienssearch < 90% 101 100%
Y PROTEIN (TRKA RECEPTOR) P04629 (282-382) (NTRK1_HUMAN)search Homo sapienssearch < 90% 101 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01138 (122 - 241) PROTEIN (NERVE GROWTH FACTOR) Homo sapiens
P04629 (282 - 382) PROTEIN (TRKA RECEPTOR) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
V, W Neurotrophinsearch Cystine-knot cytokinessearch Nerve growth factor familysearch
X, Y I set domainssearch Immunoglobulinssearch Immunoglobulin domainsearch

Chain ID Molecular function (GO)
V, W (P01138) receptor bindingsearch

Chain InterPro annotation
V, W Nerve growth factor-relatedsearch Nerve growth factor conserved sitesearch Nerve growth factor-likesearch Nerve growth factor, beta subunitsearch
X, Y Immunoglobulin I-setsearch Immunoglobulin-like foldsearch