› 1wwl

X-ray diffraction
2.5Å resolution

Crystal structure of CD14

Released:
DOI: 10.2210/pdb1wwl/pdb
PDB entry 1wwl coloured by chain, front view.
PDB entry 1wwl coloured by chain, side view.
PDB entry 1wwl coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of CD14 and its implications for lipopolysaccharide signaling.
Kim JI, Lee CJ, Jin MS, Lee CH, Paik SG, Lee H, Lee JO
J Biol Chem 280 11347-51 (2005)
PMID: 15644310

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145460 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Monocyte differentiation antigen CD14 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 33.71 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10810 (Residues: 20-329; Coverage: 88%)
Gene name: Cd14
Sequence domains: Leucine Rich Repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P212121
Unit cell:
a: 70.519Å b: 117.705Å c: 102.395Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.278
Expression system: Spodoptera frugiperda

Quick links

Citations

49 review citations

Plant NBS-LRR proteins: adaptable guards.
McHale et al. (2006)
48 more

12 mentions without citation

Peptidoglycan O-Acetylation as a Virulence Factor: Its Effect on Lysozyme in the Innate Immune System.
Brott et al. (2019)
11 more