1wrr Summary


Urate oxidase from aspergillus flavus complexed with 5-amino 6-nitro uracil

The structure was published by Retailleau, P., Colloc'h, N., Vivares, D., et al., Castro, B., El Hajji, M., and Prange, T., in 2005 in a paper entitled "Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.64 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Uricase. This molecule has the UniProt identifier Q00511 (URIC_ASPFL)search. The sample contained 301 residues which is 100% of the natural sequence. Out of 301 residues 295 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Uricase Q00511 (2-302) (URIC_ASPFL)search Aspergillus flavussearch 98% 301 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q00511 (2 - 302) Uricase Aspergillus flavus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q00511) Urate oxidase (uricase)search Urate Oxidase;search PF01014: Uricasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q00511) urate oxidase activitysearch oxidoreductase activitysearch peroxisomesearch purine nucleobase metabolic processsearch urate catabolic processsearch oxidation-reduction processsearch

Chain InterPro annotation
A Uricasesearch Uricase, conserved sitesearch