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Crystal structure of the N-terminal domain of human cardiac troponin C in complex with trifluoperazine (orthrombic crystal form)

X-ray diffraction
2.15Å resolution
PDB entry 1wrk coloured by chain, front view.
PDB entry 1wrk coloured by chain, side view.
PDB entry 1wrk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Troponin C, slow skeletal and cardiac muscles
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Multimeric state: homo dimer
Accessible surface area: 9002.12 Å2
Buried surface area: 4560.51 Å2
Dissociation area: 1,421.82 Å2
Dissociation energy (ΔGdiss): -16.53 kcal/mol
Dissociation entropy (TΔSdiss): 11.02 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-159089

Macromolecules

Troponin C, slow skeletal and cardiac muscles
Chains: A, B
Length: 88 amino acids
Theoretical weight: 9.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-88; Coverage: 55%)
Gene names: TNNC, TNNC1
Pfam: EF-hand domain pair
InterPro:
CATH: EF-hand
SCOP: Calmodulin-like
Troponin C, slow skeletal and cardiac muscles in PDB entry 1wrk, assembly 1, front view.
Troponin C, slow skeletal and cardiac muscles in PDB entry 1wrk, assembly 1, side view.
Troponin C, slow skeletal and cardiac muscles in PDB entry 1wrk, assembly 1, top view.
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