› 1wep

Solution NMR

Solution structure of PHD domain in PHF8

Released:
DOI: 10.2210/pdb1wep/pdb
PDB entry 1wep coloured by chain, ensemble of 20 models, front view.
PDB entry 1wep coloured by chain, ensemble of 20 models, side view.
PDB entry 1wep coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Entry authors: He F, Inoue M, Kigawa T, Shirouzu M, Terada T, Muto Y, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reactions catalysed: 
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(36) + 2-oxoglutarate + O(2) = a [histone H3]-N(6)-methyl-L-lysine(36) + succinate + formaldehyde + CO(2)
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(9) + 2-oxoglutarate + O(2) = a [histone H3]-N(6)-methyl-L-lysine(9) + succinate + formaldehyde + CO(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182360 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone lysine demethylase PHF8 Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 8.59 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q80TJ7 (Residues: 1-63; Coverage: 6%)
Gene names: Kiaa1111, Phf8
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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