1wd8 Summary

pdbe.org/1wd8
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Calcium free form of human peptidylarginine deiminase type4 (PAD4)

The structure was published by Arita, K., Hashimoto, H., Shimizu, T., Nakashima, K., Yamada, M., and Sato, M., in 2004 in a paper entitled "Structural basis for Ca(2+)-induced activation of human PAD4" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein-arginine deiminase type IV. This molecule has the UniProt identifier Q9UM07 (PADI4_HUMAN)search. The sample contained 670 residues which is 100% of the natural sequence. Out of 670 residues 559 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein-arginine deiminase type IV Q9UM07 (1-663) (PADI4_HUMAN)search Homo sapienssearch 100% 670 83%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UM07 (1 - 663) Protein-arginine deiminase type IV Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (Q9UM07) Peptidylarginine deiminase Pad4, middle domainsearch, Peptidylarginine deiminase Pad4, N-terminal domainsearch, Peptidylarginine deiminase Pad4, catalytic C-terminal domainsearch PF03068: Protein-arginine deiminase (PAD)search, PF08526: Protein-arginine deiminase (PAD) N-terminal domainsearch, PF08527: Protein-arginine deiminase (PAD) middle domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q9UM07) calcium ion bindingsearch protein-arginine deiminase activitysearch protein bindingsearch metal ion bindingsearch hydrolase activitysearch arginine deiminase activitysearch cytoplasmsearch nucleussearch histone citrullinationsearch chromatin modificationsearch stem cell maintenancesearch histone H3-R26 citrullinationsearch cellular protein modification processsearch protein citrullinationsearch nucleosome assemblysearch chromatin remodelingsearch regulation of transcription, DNA-templatedsearch transcription, DNA-templatedsearch innate immune responsesearch immune system processsearch

Chain InterPro annotation
A Protein-arginine deiminasesearch Cupredoxinsearch Protein-arginine deiminase, C-terminalsearch Protein-arginine deiminase (PAD) N-terminalsearch Protein-arginine deiminase (PAD), central domainsearch Protein-arginine deiminase, subgroupsearch