1wd8 Summary


Calcium free form of human peptidylarginine deiminase type4 (PAD4)

The structure was published by Arita, K., Hashimoto, H., Shimizu, T., Nakashima, K., Yamada, M., and Sato, M., in 2004 in a paper entitled "Structural basis for Ca(2+)-induced activation of human PAD4" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein-arginine deiminase type IV. This molecule has the UniProt identifier Q9UM07 (PADI4_HUMAN)search. The sample contained 670 residues which is 100% of the natural sequence. Out of 670 residues 559 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein-arginine deiminase type IV Q9UM07 (1-663) (PADI4_HUMAN)search Homo sapienssearch 100% 670 83%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UM07 (1 - 663) Protein-arginine deiminase type IV Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A (Q9UM07) Peptidylarginine deiminase Pad4, middle domainsearch, Peptidylarginine deiminase Pad4, N-terminal domainsearch, Peptidylarginine deiminase Pad4, catalytic C-terminal domainsearch PF03068: Protein-arginine deiminase (PAD)search, PF08526: Protein-arginine deiminase (PAD) N-terminal domainsearch, PF08527: Protein-arginine deiminase (PAD) middle domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q9UM07) calcium ion bindingsearch protein-arginine deiminase activitysearch protein bindingsearch metal ion bindingsearch hydrolase activitysearch arginine deiminase activitysearch cytoplasmsearch nucleussearch histone citrullinationsearch chromatin modificationsearch stem cell maintenancesearch histone H3-R26 citrullinationsearch cellular protein modification processsearch protein citrullinationsearch nucleosome assemblysearch chromatin remodelingsearch regulation of transcription, DNA-templatedsearch transcription, DNA-templatedsearch innate immune responsesearch immune system processsearch

Chain InterPro annotation
A Protein-arginine deiminasesearch Cupredoxinsearch Protein-arginine deiminase, C-terminalsearch Protein-arginine deiminase (PAD) N-terminalsearch Protein-arginine deiminase (PAD), central domainsearch Protein-arginine deiminase, subgroupsearch