› 1wd2

Solution NMR

Solution Structure of the C-terminal RING from a RING-IBR-RING (TRIAD) motif

Released:
DOI: 10.2210/pdb1wd2/pdb
PDB entry 1wd2 coloured by chain, ensemble of 20 models, front view.
PDB entry 1wd2 coloured by chain, ensemble of 20 models, side view.
PDB entry 1wd2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING.
Capili AD, Edghill EL, Wu K, Borden KL
J Mol Biol 340 1117-29 (2004)
PMID: 15236971

Function and Biology Details

Reaction catalysed: 
(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195254 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase ARIH1 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y4X5 (Residues: 336-394; Coverage: 11%)
Gene names: ARI, ARIH1, HUSSY-27, MOP6, UBCH7BP

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, followed by simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Structural and functional insights to ubiquitin-like protein conjugation.
Streich et al. (2014)
4 more

7 mentions without citation

The ring between ring fingers (RBR) protein family.
Eisenhaber et al. (2007)
6 more