1wcs Summary



The structure was published by Paris, G., Ratier, L., Amaya, M.F., Nguyen, T., Alzari, P.M., and Frasch, C., in 2005 in a paper entitled "A Sialidase Mutant Displaying Trans-Sialidase Activity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of SIALIDASE.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SIALIDASE O44049 (23-660) (O44049_TRYRA)search Trypanosoma rangelisearch 100% 641 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O44049 (23 - 660) SIALIDASE Trypanosoma rangeli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (O44049) Trypanosoma sialidase, C-terminal domainsearch, Sialidases (neuraminidases)search Neuraminidasesearch, Jelly Rollssearch PF13385: Concanavalin A-like lectin/glucanases superfamilysearch

Chain ID Molecular function (GO) Biological process (GO)
A (O44049) exo-alpha-(2->3)-sialidase activitysearch exo-alpha-sialidase activitysearch hydrolase activity, acting on glycosyl bondssearch hydrolase activitysearch exo-alpha-(2->6)-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch pathogenesissearch metabolic processsearch

Chain InterPro annotation
A Trypanosome sialidasesearch search Sialidasessearch Concanavalin A-like lectin/glucanase domainsearch Sialidase familysearch