1wbw Summary

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IDENTIFICATION OF NOVEL P38 ALPHA MAP KINASE INHIBITORS USING FRAGMENT-BASED LEAD GENERATION.

The structure was published by Gill, A., Frederickson, M., Cleasby, A., et al., Murray, C.W., Carr, R.A.E., and Jhoti, H., in 2005 in a paper entitled "Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.41 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MITOGEN-ACTIVATED PROTEIN KINASE 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) MITOGEN-ACTIVATED PROTEIN KINASE 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch MAP kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch nucleotide bindingsearch NFAT protein bindingsearch kinase activitysearch transferase activitysearch MAP kinase kinase activitysearch protein phosphorylationsearch innate immune responsesearch positive regulation of muscle cell differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch transcription, DNA-templatedsearch activation of MAPK activitysearch MyD88-independent toll-like receptor signaling pathwaysearch intracellular signal transductionsearch toll-like receptor 4 signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of myotube differentiationsearch response to muramyl dipeptidesearch DNA damage checkpointsearch response to stresssearch stress-activated MAPK cascadesearch apoptotic processsearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch positive regulation of myoblast differentiationsearch striated muscle cell differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch peptidyl-serine phosphorylationsearch RNA metabolic processsearch Ras protein signal transductionsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch gene expressionsearch platelet activationsearch response to lipopolysaccharidesearch cell surface receptor signaling pathwaysearch cellular response to lipopolysaccharidesearch regulation of transcription from RNA polymerase II promotersearch glucose metabolic processsearch chemotaxissearch positive regulation of myoblast fusionsearch cartilage condensationsearch phosphorylationsearch toll-like receptor 2 signaling pathwaysearch p38MAPK cascadesearch osteoclast differentiationsearch angiogenesissearch toll-like receptor 5 signaling pathwaysearch regulation of transcription, DNA-templatedsearch fatty acid oxidationsearch cellular response to ionizing radiationsearch signal transductionsearch toll-like receptor 10 signaling pathwaysearch signal transduction in response to DNA damagesearch skeletal muscle tissue developmentsearch vascular endothelial growth factor receptor signaling pathwaysearch stress-induced premature senescencesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of protein import into nucleussearch blood coagulationsearch toll-like receptor 9 signaling pathwaysearch chondrocyte differentiationsearch cellular response to vascular endothelial growth factor stimulussearch TRIF-dependent toll-like receptor signaling pathwaysearch cellular component movementsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of erythrocyte differentiationsearch mRNA metabolic processsearch cell morphogenesissearch cellular response to DNA damage stimulussearch muscle cell differentiationsearch cytosolsearch cytoplasmsearch nucleoplasmsearch cellsearch nucleussearch mitochondrionsearch extracellular vesicular exosomesearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch