1wbv Summary



The structure was published by Gill, A.L., Frederickson, M., Cleasby, A., et al., Murray, C.W., Carr, R.A., and Jhoti, H., in 2005 in a paper entitled "Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MITOGEN-ACTIVATED PROTEIN KINASE 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) MITOGEN-ACTIVATED PROTEIN KINASE 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch protein bindingsearch kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch transferase activitysearch protein phosphorylationsearch platelet activationsearch toll-like receptor 10 signaling pathwaysearch toll-like receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch positive regulation of protein import into nucleussearch TRIF-dependent toll-like receptor signaling pathwaysearch blood coagulationsearch stress-activated MAPK cascadesearch skeletal muscle tissue developmentsearch transcription, DNA-templatedsearch osteoclast differentiationsearch apoptotic processsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of erythrocyte differentiationsearch cellular response to ionizing radiationsearch neurotrophin TRK receptor signaling pathwaysearch response to lipopolysaccharidesearch positive regulation of blood vessel endothelial cell migrationsearch DNA damage checkpointsearch Ras protein signal transductionsearch intracellular signal transductionsearch toll-like receptor 9 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch signal transduction in response to DNA damagesearch positive regulation of reactive oxygen species metabolic processsearch innate immune responsesearch response to muramyl dipeptidesearch MyD88-dependent toll-like receptor signaling pathwaysearch cell morphogenesissearch signal transductionsearch cellular component movementsearch positive regulation of muscle cell differentiationsearch RNA metabolic processsearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 2 signaling pathwaysearch angiogenesissearch cartilage condensationsearch p38MAPK cascadesearch vascular endothelial growth factor receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch regulation of transcription, DNA-templatedsearch response to stresssearch positive regulation of myoblast fusionsearch lipopolysaccharide-mediated signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch glucose metabolic processsearch phosphorylationsearch negative regulation of canonical Wnt signaling pathwaysearch chondrocyte differentiationsearch cellular response to DNA damage stimulussearch peptidyl-serine phosphorylationsearch striated muscle cell differentiationsearch positive regulation of myotube differentiationsearch stress-induced premature senescencesearch fatty acid oxidationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch MAPK cascadesearch muscle cell differentiationsearch cellular response to vascular endothelial growth factor stimulussearch cell surface receptor signaling pathwaysearch gene expressionsearch mRNA metabolic processsearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch cellular response to lipopolysaccharidesearch activation of MAPK activitysearch positive regulation of myoblast differentiationsearch chemotaxissearch cytoplasmsearch nucleoplasmsearch nucleussearch cytosolsearch cellsearch spindle polesearch extracellular vesicular exosomesearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch