1wbt Summary



The structure was published by Gill, A.L., Frederickson, M., Cleasby, A., et al., Murray, C.W., Carr, R.A., and Jhoti, H., in 2005 in a paper entitled "Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MITOGEN-ACTIVATED PROTEIN KINASE 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) MITOGEN-ACTIVATED PROTEIN KINASE 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch MAP kinase activitysearch protein bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch transferase activitysearch kinase activitysearch MAP kinase kinase activitysearch protein phosphorylationsearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch peptidyl-serine phosphorylationsearch signal transduction in response to DNA damagesearch signal transductionsearch innate immune responsesearch cell morphogenesissearch response to lipopolysaccharidesearch positive regulation of myoblast fusionsearch toll-like receptor signaling pathwaysearch chondrocyte differentiationsearch mRNA metabolic processsearch positive regulation of myoblast differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch response to stresssearch RNA metabolic processsearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of reactive oxygen species metabolic processsearch cellular response to lipopolysaccharidesearch positive regulation of myotube differentiationsearch toll-like receptor 9 signaling pathwaysearch fatty acid oxidationsearch DNA damage checkpointsearch chemotaxissearch cellular response to ionizing radiationsearch neurotrophin TRK receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch cell surface receptor signaling pathwaysearch response to muramyl dipeptidesearch striated muscle cell differentiationsearch activation of MAPK activitysearch p38MAPK cascadesearch apoptotic processsearch vascular endothelial growth factor receptor signaling pathwaysearch skeletal muscle tissue developmentsearch platelet activationsearch toll-like receptor 4 signaling pathwaysearch MAPK cascadesearch positive regulation of protein import into nucleussearch regulation of transcription, DNA-templatedsearch negative regulation of canonical Wnt signaling pathwaysearch cartilage condensationsearch cellular response to DNA damage stimulussearch intracellular signal transductionsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of erythrocyte differentiationsearch osteoclast differentiationsearch angiogenesissearch MyD88-dependent toll-like receptor signaling pathwaysearch phosphorylationsearch TRIF-dependent toll-like receptor signaling pathwaysearch stress-activated MAPK cascadesearch toll-like receptor 2 signaling pathwaysearch stress-induced premature senescencesearch positive regulation of muscle cell differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch Ras protein signal transductionsearch cellular component movementsearch muscle cell differentiationsearch blood coagulationsearch toll-like receptor 10 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch transcription, DNA-templatedsearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch glucose metabolic processsearch cellular response to vascular endothelial growth factor stimulussearch gene expressionsearch nucleussearch nucleoplasmsearch cytoplasmsearch cytosolsearch mitochondrionsearch extracellular vesicular exosomesearch spindle polesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch