1wbt Summary



The structure was published by Gill, A.L., Frederickson, M., Cleasby, A., et al., Murray, C.W., Carr, R.A., and Jhoti, H., in 2005 in a paper entitled "Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MITOGEN-ACTIVATED PROTEIN KINASE 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) MITOGEN-ACTIVATED PROTEIN KINASE 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch protein kinase activitysearch ATP bindingsearch protein bindingsearch transferase activitysearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch angiogenesissearch response to lipopolysaccharidesearch DNA damage checkpointsearch muscle cell differentiationsearch chondrocyte differentiationsearch cellular component movementsearch striated muscle cell differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to vascular endothelial growth factor stimulussearch MyD88-independent toll-like receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch cartilage condensationsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of protein import into nucleussearch blood coagulationsearch toll-like receptor 10 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch fatty acid oxidationsearch regulation of transcription, DNA-templatedsearch Ras protein signal transductionsearch glucose metabolic processsearch osteoclast differentiationsearch innate immune responsesearch negative regulation of canonical Wnt signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch positive regulation of myoblast differentiationsearch cellular response to DNA damage stimulussearch positive regulation of myoblast fusionsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of myotube differentiationsearch toll-like receptor signaling pathwaysearch signal transduction in response to DNA damagesearch signal transductionsearch vascular endothelial growth factor receptor signaling pathwaysearch mRNA metabolic processsearch response to muramyl dipeptidesearch platelet activationsearch toll-like receptor 4 signaling pathwaysearch p38MAPK cascadesearch chemotaxissearch toll-like receptor 9 signaling pathwaysearch cellular response to ionizing radiationsearch neurotrophin TRK receptor signaling pathwaysearch phosphorylationsearch cell surface receptor signaling pathwaysearch activation of MAPK activitysearch myoblast differentiation involved in skeletal muscle regenerationsearch transcription, DNA-templatedsearch cellular response to lipopolysaccharidesearch response to stresssearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of reactive oxygen species metabolic processsearch RNA metabolic processsearch positive regulation of muscle cell differentiationsearch peptidyl-serine phosphorylationsearch apoptotic processsearch stress-induced premature senescencesearch positive regulation of erythrocyte differentiationsearch skeletal muscle tissue developmentsearch TRIF-dependent toll-like receptor signaling pathwaysearch cell morphogenesissearch intracellular signal transductionsearch 3'-UTR-mediated mRNA stabilizationsearch toll-like receptor 2 signaling pathwaysearch stress-activated MAPK cascadesearch gene expressionsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch cytosolsearch cytoplasmsearch mitochondrionsearch spindle polesearch nucleoplasmsearch nucleussearch extracellular vesicular exosomesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch