1wbo Summary

pdbe.org/1wbo
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FRAGMENT BASED P38 INHIBITORS

The structure was published by Hartshorn, M.J., Murray, C.W., Cleasby, A., Frederickson, M., Tickle, I.J., and Jhoti, H., in 2005 in a paper entitled "Fragment-Based Lead Discovery Using X-Ray Crystallography" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.16 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MITOGEN-ACTIVATED PROTEIN KINASE 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) MITOGEN-ACTIVATED PROTEIN KINASE 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch MAP kinase activitysearch protein bindingsearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch MAP kinase kinase activitysearch nucleotide bindingsearch kinase activitysearch protein phosphorylationsearch mRNA metabolic processsearch osteoclast differentiationsearch skeletal muscle tissue developmentsearch p38MAPK cascadesearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of muscle cell differentiationsearch response to muramyl dipeptidesearch myoblast differentiation involved in skeletal muscle regenerationsearch peptidyl-serine phosphorylationsearch striated muscle cell differentiationsearch positive regulation of myoblast differentiationsearch neurotrophin TRK receptor signaling pathwaysearch blood coagulationsearch positive regulation of transcription from RNA polymerase II promotersearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 4 signaling pathwaysearch angiogenesissearch stress-induced premature senescencesearch chondrocyte differentiationsearch DNA damage checkpointsearch apoptotic processsearch fatty acid oxidationsearch cellular response to DNA damage stimulussearch phosphorylationsearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch response to stresssearch muscle cell differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch chemotaxissearch positive regulation of myotube differentiationsearch toll-like receptor signaling pathwaysearch transcription, DNA-templatedsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch signal transductionsearch cell surface receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch stress-activated MAPK cascadesearch lipopolysaccharide-mediated signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch intracellular signal transductionsearch positive regulation of myoblast fusionsearch toll-like receptor 2 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch platelet activationsearch toll-like receptor 5 signaling pathwaysearch positive regulation of protein import into nucleussearch glucose metabolic processsearch cellular component movementsearch signal transduction in response to DNA damagesearch response to lipopolysaccharidesearch negative regulation of canonical Wnt signaling pathwaysearch cellular response to lipopolysaccharidesearch gene expressionsearch RNA metabolic processsearch innate immune responsesearch Ras protein signal transductionsearch cellular response to vascular endothelial growth factor stimulussearch 3'-UTR-mediated mRNA stabilizationsearch toll-like receptor 9 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch positive regulation of erythrocyte differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch cellular response to ionizing radiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cartilage condensationsearch activation of MAPK activitysearch positive regulation of reactive oxygen species metabolic processsearch cell morphogenesissearch nucleoplasmsearch extracellular vesicular exosomesearch nucleussearch cytosolsearch cytoplasmsearch spindle polesearch cellsearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch