1wbn Summary



The structure was published by Gill, A.L., Frederickson, M., Cleasby, A., et al., Murray, C.W., Carr, R.A., and Jhoti, H., in 2005 in a paper entitled "Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MITOGEN-ACTIVATED PROTEIN KINASE 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) MITOGEN-ACTIVATED PROTEIN KINASE 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch ATP bindingsearch protein kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch protein bindingsearch transferase activitysearch protein serine/threonine kinase activitysearch kinase activitysearch MAP kinase kinase activitysearch protein phosphorylationsearch MyD88-dependent toll-like receptor signaling pathwaysearch signal transduction in response to DNA damagesearch blood coagulationsearch chemotaxissearch toll-like receptor 4 signaling pathwaysearch striated muscle cell differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor signaling pathwaysearch osteoclast differentiationsearch movement of cell or subcellular componentsearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch positive regulation of protein import into nucleussearch mitochondrion organizationsearch toll-like receptor 9 signaling pathwaysearch p38MAPK cascadesearch peptidyl-serine phosphorylationsearch muscle cell differentiationsearch positive regulation of brown fat cell differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of reactive oxygen species metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch Ras protein signal transductionsearch positive regulation of myoblast fusionsearch lipopolysaccharide-mediated signaling pathwaysearch glucose metabolic processsearch intracellular signal transductionsearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of myotube differentiationsearch cellular response to ionizing radiationsearch activation of MAPK activitysearch TRIF-dependent toll-like receptor signaling pathwaysearch cellular response to DNA damage stimulussearch gene expressionsearch toll-like receptor 2 signaling pathwaysearch fatty acid oxidationsearch response to lipopolysaccharidesearch skeletal muscle tissue developmentsearch phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch angiogenesissearch platelet activationsearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 10 signaling pathwaysearch organelle organizationsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of myoblast differentiationsearch cell surface receptor signaling pathwaysearch chondrocyte differentiationsearch DNA damage checkpointsearch regulation of transcription, DNA-templatedsearch regulation of sequence-specific DNA binding transcription factor activitysearch myoblast differentiation involved in skeletal muscle regenerationsearch cell morphogenesissearch response to muramyl dipeptidesearch signal transductionsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to lipopolysaccharidesearch stress-induced premature senescencesearch transcription, DNA-templatedsearch innate immune responsesearch positive regulation of muscle cell differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch cartilage condensationsearch stress-activated MAPK cascadesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch apoptotic processsearch cytosolsearch cytoplasmsearch mitochondrionsearch nucleoplasmsearch nucleussearch spindle polesearch extracellular vesicular exosomesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch