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CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN

X-ray diffraction
2.5Å resolution
PDB entry 1wav coloured by chain, front view.
PDB entry 1wav coloured by chain, side view.
PDB entry 1wav coloured by chain, top view.
Source organism: Sus scrofa
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
hetero dodecamer
hetero hexamer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 3860.96 Å2
Buried surface area: 1778.3 Å2
Dissociation area: 752.39 Å2
Dissociation energy (ΔGdiss): 6.95 kcal/mol
Dissociation entropy (TΔSdiss): 8.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 10
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Assembly Name: Insulin B chain
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Multimeric state: hetero tetramer
Accessible surface area: 6448.42 Å2
Buried surface area: 4727.25 Å2
Dissociation area: 617.49 Å2
Dissociation energy (ΔGdiss): 4.04 kcal/mol
Dissociation entropy (TΔSdiss): 9.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134242
Assembly 11
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Assembly Name: Insulin B chain
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Multimeric state: hetero tetramer
Accessible surface area: 6211.62 Å2
Buried surface area: 4813.65 Å2
Dissociation area: 819.75 Å2
Dissociation energy (ΔGdiss): 1.98 kcal/mol
Dissociation entropy (TΔSdiss): 9.79 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134242
Assembly 12
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Assembly Name: Insulin B chain
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Multimeric state: hetero tetramer
Accessible surface area: 6607.93 Å2
Buried surface area: 4025.83 Å2
Dissociation area: 715.05 Å2
Dissociation energy (ΔGdiss): 2.87 kcal/mol
Dissociation entropy (TΔSdiss): 9.77 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134242
Assembly 2
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 3822.44 Å2
Buried surface area: 1713.98 Å2
Dissociation area: 715.55 Å2
Dissociation energy (ΔGdiss): 7.44 kcal/mol
Dissociation entropy (TΔSdiss): 8.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 3
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 3784.95 Å2
Buried surface area: 1531.48 Å2
Dissociation area: 684.78 Å2
Dissociation energy (ΔGdiss): 5.57 kcal/mol
Dissociation entropy (TΔSdiss): 8.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 4
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 3993.19 Å2
Buried surface area: 1715.65 Å2
Dissociation area: 690.9 Å2
Dissociation energy (ΔGdiss): 4.28 kcal/mol
Dissociation entropy (TΔSdiss): 8.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 5
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 3851.5 Å2
Buried surface area: 1522.48 Å2
Dissociation area: 687.7 Å2
Dissociation energy (ΔGdiss): 4.16 kcal/mol
Dissociation entropy (TΔSdiss): 8.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 6
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Assembly Name: Insulin B chain
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Multimeric state: hetero dimer
Accessible surface area: 4182.02 Å2
Buried surface area: 1077.77 Å2
Dissociation area: 538.89 Å2
Dissociation energy (ΔGdiss): 6.41 kcal/mol
Dissociation entropy (TΔSdiss): 8.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134237
Assembly 7
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Assembly Name: Insulin B chain
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Multimeric state: hetero dodecamer
Accessible surface area: 13433.58 Å2
Buried surface area: 19401.13 Å2
Dissociation area: 187.91 Å2
Dissociation energy (ΔGdiss): 79.53 kcal/mol
Dissociation entropy (TΔSdiss): -0.39 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134248
Assembly 8
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Assembly Name: Insulin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 9395.52 Å2
Buried surface area: 6934.14 Å2
Dissociation area: 1,375.67 Å2
Dissociation energy (ΔGdiss): 30.34 kcal/mol
Dissociation entropy (TΔSdiss): 19.6 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134245
Assembly 9
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Assembly Name: Insulin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 9819.14 Å2
Buried surface area: 6685.92 Å2
Dissociation area: 1,126.41 Å2
Dissociation energy (ΔGdiss): 33.23 kcal/mol
Dissociation entropy (TΔSdiss): 19.53 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134245

Macromolecules

Insulin A chain
Chains: A, C, E, G, I, K
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 88-108; Coverage: 25%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1wav, assembly 1, front view.
Insulin A chain in PDB entry 1wav, assembly 1, side view.
Insulin A chain in PDB entry 1wav, assembly 1, top view.
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Insulin B chain
Chains: B, D, F, H, J, L
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P01315 (Residues: 25-54; Coverage: 36%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1wav, assembly 1, front view.
Insulin B chain in PDB entry 1wav, assembly 1, side view.
Insulin B chain in PDB entry 1wav, assembly 1, top view.
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