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EBI PDBe PDBeView

PDBe Entry: 1w96 view

CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE DOMAIN OF ACETYL-COENZYME A CARBOXYLASE FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH SORAPHEN A
Summary
Header LIGASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.8 Å, R-factor: 19.5%, Free R-factor: 23.0%, Spacegroup: P 1 21 1
Released 04/01/2005, deposition: 06/10/2004, last revision: 24/02/2009
Authors Shen, Y.search; Volrath, S.L.search; Weatherly, S.C.search; Elich, T.D.search; Tong, L.search
Primary citation A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
MOL.CELLsearch vol:16, pag:881 (2004) [PubMed ID 15610732 ]search
Keywords LIGASEsearch, OBESITYsearch, DIABETESsearch, FATTY ACID METABOLISMsearch, STRUCTURE-BASED DRUG DESIGNsearch, ALLOSTERIC INHIBITIONsearch, POLYKETIDEsearch
EC 6.3.4.14 ExPASy BRENDA search 6.4.1.2 ExPASy BRENDA search (A B C)
Organism Saccharomyces cerevisiae(baker's yeast) 4932search(A B C)
UniProt Acetyl-CoA carboxylase (EC 6.4.1.2) (ACC) [Includes: Biotin carboxylase (EC 6.3.4.14)] Q00955search (A B C)
Solvent A, B, C
Related entries 1od2, 1od4, 1uyr, 1uys, 1uyt, 1uyv, 1w2x, 1w93
Polymers
Id Name Type UniProt Residues Observed
A, B, C ACETYL-COENZYME A CARBOXYLASE Protein Q00955 (ACAC_YEAST)search
 554 99%
Heterogens
Id Name Ligands
A, B, C SORAPHEN A S1A search
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