1w8o Summary

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CONTRIBUTION OF THE ACTIVE SITE ASPARTIC ACID TO CATALYSIS IN THE BACTERIAL NEURAMINIDASE FROM MICROMONOSPORA VIRIDIFACIENS

The structure was published by Watson, J.N., Newstead, S., Dookhun, V., Taylor, G., and Bennet, A.J., in 2004 in a paper entitled "Contribution of the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora Viridifaciens" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of BACTERIAL SIALIDASE. This molecule has the UniProt identifier Q02834 (NANH_MICVI)search. The sample contained 601 residues which is 99% of the natural sequence. Out of 601 residues 601 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BACTERIAL SIALIDASE Q02834 (47-647) (NANH_MICVI)search Micromonospora viridifacienssearch 99% 601 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q02834 (47 - 647) BACTERIAL SIALIDASE Micromonospora viridifaciens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q02834) E-set domains of sugar-utilizing enzymessearch, Galactose-binding domainsearch, Sialidases (neuraminidases)search Neuraminidasesearch, Immunoglobulinssearch, Galactose-binding domain-likesearch PF00754: F5/8 type C domainsearch, PF10633: NPCBM-associated, NEW3 domain of alpha-galactosidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q02834) pathogenesissearch metabolic processsearch cell adhesionsearch exo-alpha-sialidase activitysearch hydrolase activity, acting on glycosyl bondssearch exo-alpha-(2->6)-sialidase activitysearch exo-alpha-(2->3)-sialidase activitysearch hydrolase activitysearch exo-alpha-(2->8)-sialidase activitysearch extracellular regionsearch

Chain InterPro annotation
A Coagulation factor 5/8 C-terminal type domainsearch Galactose-binding domain-likesearch Sialidasessearch Immunoglobulin-like foldsearch Immunoglobulin E-setsearch Alpha-galactosidase, NEW3 domainsearch Sialidase familysearch