Function and Biology

Contribution of the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora viridifaciens.

EC 3.2.1.18: Exo-alpha-sialidase

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
  • Acetylneuraminidase
  • Alpha-neuraminidase
  • N-acylneuraminate glycohydrolase
  • Neuraminidase
  • Sialidase

Sequence families

Pfam Protein families (Pfam)
PF00754
Domain description: F5/8 type C domain
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 1w8n contains 1 copy of Pfam domain PF00754 (F5/8 type C domain) in Sialidase. Showing 1 copy in chain A.

PF10633
Domain description: NPCBM-associated, NEW3 domain of alpha-galactosidase
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 1w8n contains 1 copy of Pfam domain PF10633 (NPCBM-associated, NEW3 domain of alpha-galactosidase) in Sialidase. Showing 1 copy in chain A.

PF13088
Domain description: BNR repeat-like domain
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 1w8n contains 1 copy of Pfam domain PF13088 (BNR repeat-like domain) in Sialidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000421
Domain description: Coagulation factor 5/8 C-terminal domain
Occurring in:
  1. Sialidase
IPR008979
Domain description: Galactose-binding-like domain superfamily
Occurring in:
  1. Sialidase
IPR018905
Domain description: Alpha-galactosidase, NEW3 domain
Occurring in:
  1. Sialidase
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Sialidase
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Sialidase
IPR011040
Domain description: Sialidase
Occurring in:
  1. Sialidase
IPR026856
Domain description: Sialidase family
Occurring in:
  1. Sialidase
IPR036278
Domain description: Sialidase superfamily
Occurring in:
  1. Sialidase

Structure domains

CATH CATH domains
2.60.120.260
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Galactose-binding domain-like
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 1w8n contains 1 copy of CATH domain 2.60.120.260 (Jelly Rolls) in Sialidase. Showing 1 copy in chain A.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 1w8n contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Sialidase. Showing 1 copy in chain A.
2.120.10.10
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Neuraminidase
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 1w8n contains 1 copy of CATH domain 2.120.10.10 (Neuraminidase) in Sialidase. Showing 1 copy in chain A.
SCOP SCOP annotations
49786
Class: All beta proteins
Fold: Galactose-binding domain-like
Superfamily: Galactose-binding domain-like
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 1w8n contains 1 copy of SCOP domain 49786 (Galactose-binding domain) in Sialidase. Showing 1 copy in chain A.
81282
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 1w8n contains 1 copy of SCOP domain 81282 (E-set domains of sugar-utilizing enzymes) in Sialidase. Showing 1 copy in chain A.
50940
Class: All beta proteins
Fold: 6-bladed beta-propeller
Superfamily: Sialidases
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 1w8n contains 1 copy of SCOP domain 50940 (Sialidases (neuraminidases)) in Sialidase. Showing 1 copy in chain A.