1w8c Summary

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CO-CRYSTAL STRUCTURE OF 6-CYCLOHEXYLMETHOXY-8-ISOPROPYL-9H-PURIN-2- YLAMINE AND MONOMERIC CDK2

The structure was published by Carbain, B., Paterson, D.J., Anscombe, E., et al., Roche, C., Wang, L., and Griffin, R.J., in 2014 in a paper entitled "8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P24941) ATP bindingsearch protein kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch metal ion bindingsearch nucleotide bindingsearch cyclin bindingsearch kinase activitysearch histone kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleoplasmsearch cytosolsearch cytoskeletonsearch X chromosomesearch centrosomesearch chromosome, telomeric regionsearch nucleussearch Cajal bodysearch condensed chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch cytoplasmsearch endosomesearch microtubule organizing centersearch transcription factor complexsearch Y chromosomesearch cellular response to DNA damage stimulussearch positive regulation of DNA-dependent DNA replication initiationsearch DNA repairsearch positive regulation of cell proliferationsearch G1/S transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch DNA replicationsearch cell divisionsearch positive regulation of transcription, DNA-templatedsearch cellular response to nitric oxidesearch G2/M transition of mitotic cell cyclesearch Ras protein signal transductionsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch protein phosphorylationsearch blood coagulationsearch centrosome duplicationsearch mitotic G1 DNA damage checkpointsearch meiotic nuclear divisionsearch histone phosphorylationsearch potassium ion transportsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic cell cyclesearch phosphorylationsearch regulation of gene silencingsearch mitotic nuclear divisionsearch cell cyclesearch meiotic cell cyclesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch