1w83 Summary

pdbe.org/1w83
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P38 KINASE CRYSTAL STRUCTURE IN COMPLEX WITH SMALL MOLECULE INHIBITOR

The structure was published by Gill, A., Frederickson, M., Cleasby, A., et al., Murray, C., Carr, R., and Jhoti, H., in 2005 in a paper entitled "Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MITOGEN-ACTIVATED PROTEIN KINASE 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) MITOGEN-ACTIVATED PROTEIN KINASE 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein bindingsearch MAP kinase kinase activitysearch MAP kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch transferase activitysearch protein phosphorylationsearch cellular response to lipopolysaccharidesearch innate immune responsesearch MyD88-dependent toll-like receptor signaling pathwaysearch platelet activationsearch cartilage condensationsearch positive regulation of erythrocyte differentiationsearch angiogenesissearch activation of MAPK activitysearch skeletal muscle tissue developmentsearch intracellular signal transductionsearch cellular component movementsearch p38MAPK cascadesearch toll-like receptor 9 signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of muscle cell differentiationsearch response to muramyl dipeptidesearch phosphorylationsearch chemotaxissearch toll-like receptor 4 signaling pathwaysearch response to lipopolysaccharidesearch myoblast differentiation involved in skeletal muscle regenerationsearch glucose metabolic processsearch positive regulation of myoblast fusionsearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor 5 signaling pathwaysearch signal transduction in response to DNA damagesearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor signaling pathwaysearch blood coagulationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch gene expressionsearch regulation of transcription from RNA polymerase II promotersearch apoptotic processsearch stress-activated MAPK cascadesearch lipopolysaccharide-mediated signaling pathwaysearch DNA damage checkpointsearch toll-like receptor 10 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch transcription, DNA-templatedsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of myoblast differentiationsearch cellular response to DNA damage stimulussearch peptidyl-serine phosphorylationsearch toll-like receptor 2 signaling pathwaysearch cell surface receptor signaling pathwaysearch cell morphogenesissearch osteoclast differentiationsearch TRIF-dependent toll-like receptor signaling pathwaysearch chondrocyte differentiationsearch positive regulation of myotube differentiationsearch cellular response to ionizing radiationsearch positive regulation of protein import into nucleussearch signal transductionsearch toll-like receptor 3 signaling pathwaysearch response to stresssearch mRNA metabolic processsearch muscle cell differentiationsearch regulation of sequence-specific DNA binding transcription factor activitysearch striated muscle cell differentiationsearch RNA metabolic processsearch regulation of transcription, DNA-templatedsearch MyD88-independent toll-like receptor signaling pathwaysearch stress-induced premature senescencesearch Ras protein signal transductionsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch fatty acid oxidationsearch negative regulation of canonical Wnt signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch nucleoplasmsearch cytosolsearch extracellular vesicular exosomesearch cytoplasmsearch spindle polesearch cellsearch mitochondrionsearch nucleussearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch