1w82 Summary

pdbe.org/1w82
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P38 KINASE CRYSTAL STRUCTURE IN COMPLEX WITH SMALL MOLECULE INHIBITOR

The structure was published by Gill, A., Frederickson, M., Cleasby, A., et al., Murray, C., Carr, R., and Jhoti, H., in 2005 in a paper entitled "Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MITOGEN-ACTIVATED PROTEIN KINASE 14.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) MITOGEN-ACTIVATED PROTEIN KINASE 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch MyD88-independent toll-like receptor signaling pathwaysearch response to muramyl dipeptidesearch p38MAPK cascadesearch toll-like receptor 9 signaling pathwaysearch angiogenesissearch peptidyl-serine phosphorylationsearch positive regulation of protein import into nucleussearch negative regulation of canonical Wnt signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch skeletal muscle tissue developmentsearch neurotrophin TRK receptor signaling pathwaysearch chondrocyte differentiationsearch cell surface receptor signaling pathwaysearch apoptotic processsearch toll-like receptor 2 signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch vascular endothelial growth factor receptor signaling pathwaysearch fatty acid oxidationsearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch regulation of transcription, DNA-templatedsearch MAPK cascadesearch osteoclast differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of reactive oxygen species metabolic processsearch platelet activationsearch positive regulation of erythrocyte differentiationsearch signal transduction in response to DNA damagesearch phosphorylationsearch toll-like receptor signaling pathwaysearch activation of MAPK activitysearch regulation of sequence-specific DNA binding transcription factor activitysearch transcription, DNA-templatedsearch toll-like receptor 5 signaling pathwaysearch cell morphogenesissearch response to stresssearch cellular component movementsearch RNA metabolic processsearch blood coagulationsearch toll-like receptor 10 signaling pathwaysearch cellular response to ionizing radiationsearch stress-induced premature senescencesearch response to lipopolysaccharidesearch innate immune responsesearch positive regulation of myotube differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch glucose metabolic processsearch cellular response to DNA damage stimulussearch lipopolysaccharide-mediated signaling pathwaysearch Ras protein signal transductionsearch positive regulation of myoblast fusionsearch muscle cell differentiationsearch intracellular signal transductionsearch mRNA metabolic processsearch cartilage condensationsearch striated muscle cell differentiationsearch positive regulation of myoblast differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of muscle cell differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to vascular endothelial growth factor stimulussearch chemotaxissearch cellular response to lipopolysaccharidesearch signal transductionsearch DNA damage checkpointsearch gene expressionsearch 3'-UTR-mediated mRNA stabilizationsearch TRIF-dependent toll-like receptor signaling pathwaysearch stress-activated MAPK cascadesearch ATP bindingsearch protein kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch transferase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch MAP kinase kinase activitysearch nucleoplasmsearch mitochondrionsearch cytosolsearch extracellular vesicular exosomesearch nucleussearch cytoplasmsearch cellsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch