1w7j Summary

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CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX - NEAR RIGOR

The structure was published by Coureux, P.-D., Sweeney, H.L., and Houdusse, A., in 2004 in a paper entitled "Three Myosin V Structures Delineate Essential Features of Chemo-Mechanical Transduction" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely MYOSIN VA and MYOSIN LIGHT CHAIN 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MYOSIN VA Q02440 (1-792) (MYO5A_CHICK)search Gallus gallussearch < 90% 795 94%
B MYOSIN LIGHT CHAIN 1 P14649 (59-208) (MYL6B_HUMAN)search Homo sapienssearch < 90% 151 86%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q02440 (1 - 792) MYOSIN VA Gallus gallus
P14649 (59 - 208) MYOSIN LIGHT CHAIN 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Myosin S1 fragment, N-terminal domainsearch, Motor proteinssearch Myosin head (motor domain)search, IQ calmodulin-binding motifsearch
B Calmodulin-likesearch EF-handsearch EF-hand domainsearch

Chain ID Cellular component (GO) Molecular function (GO)
A (Q02440) myosin complexsearch motor activitysearch ATP bindingsearch
B (P14649) calcium ion bindingsearch

Chain InterPro annotation
A IQ motif, EF-hand binding sitesearch Myosin head, motor domainsearch Myosin S1 fragment, N-terminalsearch P-loop containing nucleoside triphosphate hydrolasesearch
B EF-hand domainsearch EF-hand domain pairsearch