1w1v Summary

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CRYSTAL STRUCTURE OF S. MARCESCENS CHITINASE B IN COMPLEX WITH THE CYCLIC DIPEPTIDE INHIBITOR CYCLO-(L-ARG-L-PRO) AT 1.85 A RESOLUTION

The structure was published by Houston, D.R., Synstad, B., Eijsink, V.G.H., Stark, M.J., Eggleston, I., and Van Aalten, D.M.F., in 2004 in a paper entitled "Structure-Based Exploration of Cyclic Dipeptide Chitinase Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CHITINASE B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CHITINASE B Q54276 (1-499) (Q54276_SERMA)search Serratia marcescenssearch 100% 499 99%
B CHITINASE B Q54276 (1-499) (Q54276_SERMA)search Serratia marcescenssearch 100% 499 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q54276 (1 - 499) CHITINASE B Serratia marcescens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q54276) Glycosidasessearch, Chitinase A; domain 3search, Seminal Fluid Protein PDC-109 (Domain B)search PF00704: Glycosyl hydrolases family 18search, PF02839: Carbohydrate binding domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q54276) hydrolase activity, hydrolyzing O-glycosyl compoundssearch hydrolase activitysearch chitinase activitysearch carbohydrate bindingsearch hydrolase activity, acting on glycosyl bondssearch carbohydrate metabolic processsearch chitin catabolic processsearch metabolic processsearch extracellular regionsearch

Chain InterPro annotation
A, B Glycoside hydrolase, family 18, catalytic domainsearch Glycoside hydrolase, chitinase active sitesearch Carbohydrate-binding module family 5/12search Chitinase IIsearch Glycoside hydrolase, catalytic domainsearch Glycoside hydrolase superfamilysearch Chitinase insertion domainsearch