spacer

PDBe Entry: 1w1i view

CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPPIV OR CD26) IN COMPLEX WITH ADENOSINE DEAMINASE
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.03 Å, R-factor: 22.4%, Free R-factor: 25.7%, Spacegroup: C 1 2 1
Released 02/09/2004, deposition: 22/06/2004, last revision: 24/02/2009
Authors Weihofen, W.A.search; Liu, J.search; Reutter, W.search; Saenger, W.search; Fan, H.search
Primary citation Crystal Structure of Cd26/Dipeptidyl-Peptidase Iv in Complex with Adenosine Deaminase Reveals a Highly Amphiphilic Interface
J.BIOL.CHEM.search vol:279, pag:43330 (2004) [PubMed ID 15213224 ]search
Keywords HYDROLASEsearch, HYDROLASE/COMPLEXsearch, DIPETIDYL PEPTIDASE IVsearch, DPPIVsearch, CD26search, ALPHA/BETA-HYDROLASE FOLDsearch, BETA-PROPELLER FOLDsearch, PROTEIN-PROTEIN COMPLEXsearch, ADENOSINE DEAMINASEsearch, ADAsearch, SERINE PROTEASEsearch, AMINOPEPTIDASEsearch
EC 3.4.14.5 ExPASy BRENDA search (A B C D), 3.5.4.4 ExPASy BRENDA search (E F G H)
Organism Homo sapiens(human) 9606search(A B C D),Bos taurus(cattle) 9913search(E F G H)
UniProt Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (Adenosine deaminase complexing protein 2) (ADABP) [Contains: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)] P27487search (A B C D)
Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) P56658search (E F G H)
Related entries 1j2e, 1n1m, 1nu6, 1nu8, 1pfq, 1krm, 1ndv, 1ndw, 1ndy, 1ndz
Polymers
Id Name Type UniProt Residues Observed
A, B, C, D DIPEPTIDYL PEPTIDASE IV Protein P27487 (DPP4_HUMAN)search
728 100%
E, F, G, H ADENOSINE DEAMINASE Protein P56658 (ADA_BOVIN)search
357 98%
Heterogens
Id Name Ligands
A, C SUGAR (3-MER) NAG search FUC search
A, B, C, D SUGAR (2-MER) NAG search
A, B, C, D SUGAR (4-MER) NAG search BMA search MAN search
A, B, C, D SUGAR (N-ACETYL-D-GLUCOSAMINE) NAG search
A, B SUGAR (2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE) NDG search
B, D SUGAR (2-MER) NAG search FUC search
E, F, G, H ZINC ION ZN search
spacer