1w0x Summary


Crystal structure of human CDK2 in complex with the inhibitor olomoucine.

The structure was published by Schulze-Gahmen, U., Brandsen, J., Jones, H.D., et al., Meijer, L., Vesely, J., and Kim, S.H., in 1995 in a paper entitled "Multiple Modes of Ligand Recognition: Crystal Structures of Cyclin-Dependent Protein Kinase 2 in Complex with ATP and Two Inhibitors, Olomoucine and Isopentenyladenine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CYCLIN-DEPENDENT KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 279 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C CYCLIN-DEPENDENT KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 99% 298 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CYCLIN-DEPENDENT KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
C (P24941) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch transferase activitysearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch kinase activitysearch metal ion bindingsearch histone kinase activitysearch protein phosphorylationsearch meiotic nuclear divisionsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch histone phosphorylationsearch G2/M transition of mitotic cell cyclesearch DNA replicationsearch cell cyclesearch cell divisionsearch mitotic G1 DNA damage checkpointsearch Ras protein signal transductionsearch mitotic cell cyclesearch positive regulation of cell proliferationsearch positive regulation of transcription, DNA-templatedsearch G1/S transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to DNA damage stimulussearch mitotic G2 phasesearch mitotic nuclear divisionsearch phosphorylationsearch DNA repairsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch blood coagulationsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of gene silencingsearch cellular response to nitric oxidesearch potassium ion transportsearch centrosome duplicationsearch cytoplasmsearch nucleoplasmsearch cytosolsearch X chromosomesearch endosomesearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch condensed chromosomesearch centrosomesearch nucleussearch cytoskeletonsearch microtubule organizing centersearch chromosome, telomeric regionsearch transcription factor complexsearch Y chromosomesearch

Chain InterPro annotation
C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch