1w0o Summary

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VIBRIO CHOLERAE SIALIDASE

The structure was published by Moustafa, I., Connaris, H., Taylor, M., et al., Kiefel, J.C.Wilsonm.J., Von-Itzstein, M., and Taylor, G., in 2004 in a paper entitled "Sialic Acid Recognition by Vibrio Cholerae Neuraminidase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of SIALIDASE. This molecule has the UniProt identifier P0C6E9 (NANH_VIBCH)search. The sample contained 781 residues which is < 90% of the natural sequence. Out of 781 residues 753 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SIALIDASE P0C6E9 (1-781) (NANH_VIBCH)search Vibrio cholerae O1 biovar El Tor str. N16961search 100% 781 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0C6E9 (1 - 781) SIALIDASE Vibrio cholerae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P0C6E9) Vibrio cholerae sialidase, N-terminal and insertion domainssearch, Sialidases (neuraminidases)search Jelly Rollssearch, Neuraminidasesearch PF09264: Vibrio cholerae sialidase, lectin insertionsearch

Chain ID Molecular function (GO)
A (P0C6E9) sialic acid bindingsearch exo-alpha-sialidase activitysearch

Chain InterPro annotation
A search Sialidasessearch Concanavalin A-like lectin/glucanase domainsearch Vibrio cholerae neuraminidase, lectin-like domainsearch Sialidase familysearch