1vyz Summary

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STRUCTURE OF CDK2 COMPLEXED WITH PNU-181227

The structure was published by Pevarello, P., Brasca, M.G., Amici, R., et al., Varasi, M., Vulpetti, A., and Warpehoski, M.A., in 2004 in a paper entitled "3-Aminopyrazole Inhibitors of Cdk2/Cyclin a as Antitumor Agents. 1. Lead Finding" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.21 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 278 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch DNA repairsearch G1/S transition of mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch DNA replicationsearch positive regulation of transcription, DNA-templatedsearch mitotic nuclear divisionsearch cell cyclesearch G2/M transition of mitotic cell cyclesearch cellular response to nitric oxidesearch blood coagulationsearch centrosome duplicationsearch potassium ion transportsearch meiotic nuclear divisionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic G2 phasesearch cell divisionsearch cellular response to DNA damage stimulussearch mitotic cell cyclesearch histone phosphorylationsearch Ras protein signal transductionsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch phosphorylationsearch positive regulation of DNA-dependent DNA replication initiationsearch positive regulation of cell proliferationsearch regulation of gene silencingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch protein bindingsearch cyclin bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch transferase activitysearch histone kinase activitysearch metal ion bindingsearch cytosolsearch nucleoplasmsearch cytoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch endosomesearch nucleussearch Cajal bodysearch condensed chromosomesearch transcription factor complexsearch Y chromosomesearch X chromosomesearch cytoskeletonsearch microtubule organizing centersearch chromosome, telomeric regionsearch centrosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch