1vyw Summary

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STRUCTURE OF CDK2/CYCLIN A WITH PNU-292137

The structure was published by Pevarello, P., Brasca, M.G., Amici, R., et al., Varasi, M., Vulpetti, A., and Warpehoski, M.A., in 2004 in a paper entitled "3-Aminopyrazole Inhibitors of Cdk2/Cyclin a as Antitumor Agents. Part 1. Lead Finding" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 309 97%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 309 97%
B CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 265 97%
D CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 265 97%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (174 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein serine/threonine kinase activitysearch metal ion bindingsearch histone kinase activitysearch transferase activitysearch cyclin bindingsearch kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch cell divisionsearch blood coagulationsearch G1/S transition of mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch cellular response to DNA damage stimulussearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch DNA replicationsearch mitotic nuclear divisionsearch phosphorylationsearch meiotic nuclear divisionsearch positive regulation of transcription, DNA-templatedsearch cell cyclesearch meiotic cell cyclesearch peptidyl-serine phosphorylationsearch positive regulation of cell proliferationsearch Ras protein signal transductionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cellular response to nitric oxidesearch DNA repairsearch potassium ion transportsearch histone phosphorylationsearch mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch regulation of gene silencingsearch centrosome duplicationsearch positive regulation of DNA-dependent DNA replication initiationsearch nucleoplasmsearch endosomesearch cytoplasmsearch X chromosomesearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch transcription factor complexsearch cytosolsearch microtubule organizing centersearch cytoskeletonsearch condensed chromosomesearch Y chromosomesearch nucleussearch centrosomesearch chromosome, telomeric regionsearch
B, D (P20248) protein kinase bindingsearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin A, chordatessearch