› 1vyn

Solution NMR

STRUCTURE AND NUCLEIC ACID BINDING OF THE DROSOPHILA ARGONAUTE2 PAZ DOMAIN

Released:
DOI: 10.2210/pdb1vyn/pdb
PDB entry 1vyn coloured by chain, ensemble of 10 models, front view.
PDB entry 1vyn coloured by chain, ensemble of 10 models, side view.
PDB entry 1vyn coloured by chain, ensemble of 10 models, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain.
Lingel A, Simon B, Izaurralde E, Sattler M
Nature 426 465-9 (2003)
PMID: 14615801

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194309 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein argonaute-2 Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 16.07 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9VUQ5 (Residues: 600-740; Coverage: 12%)
Gene names: AGO2, CG7439
Sequence domains: PAZ domain
Structure domains: paz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: MOLECULAR DYNAMICS, SIMULATED ANNEALING
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

106 review citations

MicroRNAs: genomics, biogenesis, mechanism, and function.
Bartel DP. (2004)
105 more

2 mentions without citation

Crystal structures of MBP fusion proteins.
Waugh DS. (2016)
1 more