1vwt Summary

pdbe.org/1vwt
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T STATE HUMAN HEMOGLOBIN [ALPHA V96W], ALPHA AQUOMET, BETA DEOXY

The structure was published by Puius, Y.A., Zou, M., Ho, N.T., Ho, C., and Almo, S.C., in 1998 in a paper entitled "Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch membranesearch haptoglobin-hemoglobin complexsearch metal ion bindingsearch protein bindingsearch oxygen transporter activitysearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen bindingsearch positive regulation of cell deathsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch oxygen transportsearch small molecule metabolic processsearch transportsearch response to hydrogen peroxidesearch
B, D (P68871) endocytic vesicle lumensearch hemoglobin complexsearch extracellular regionsearch blood microparticlesearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch oxygen transporter activitysearch heme bindingsearch protein bindingsearch peroxidase activitysearch oxygen bindingsearch metal ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch iron ion bindingsearch regulation of blood pressuresearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch nitric oxide transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch bicarbonate transportsearch oxygen transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch renal absorptionsearch platelet aggregationsearch regulation of blood vessel sizesearch transportsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch