1vwt Summary

pdbe.org/1vwt
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T STATE HUMAN HEMOGLOBIN [ALPHA V96W], ALPHA AQUOMET, BETA DEOXY

The structure was published by Puius, Y.A., Zou, M., Ho, N.T., Ho, C., and Almo, S.C., in 1998 in a paper entitled "Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolic small ribosomal subunitsearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch membranesearch blood microparticlesearch bicarbonate transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch oxygen transportsearch oxidation-reduction processsearch small molecule metabolic processsearch response to hydrogen peroxidesearch transportsearch oxygen transporter activitysearch protein bindingsearch iron ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch
B, D (P68871) hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch nitric oxide transportsearch regulation of blood vessel sizesearch transportsearch regulation of blood pressuresearch blood coagulationsearch bicarbonate transportsearch oxygen transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch renal absorptionsearch oxidation-reduction processsearch small molecule metabolic processsearch platelet aggregationsearch iron ion bindingsearch heme bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch hemoglobin bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch