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PDBe Entry: 1vsn 
Crystal structure of a potent small molecule inhibitor bound to cathepsin K
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Hydrolase
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X-RAY DIFFRACTION
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Resolution: 2.0 Å, R-factor: 17.7%, Free R-factor: 20.9%, Spacegroup: P 21 21 21
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24/04/2007, deposition: 19/03/2007, last revision: 24/02/2009
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McGrath, M.
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Identification of a potent and selective non-basic cathepsin K inhibitor.
BIOORG.MED.CHEM.LETT. vol:16, pag:1985-1989 (2006) [PubMed ID 16413777 ]
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osteoporosis, structure-guided drug design, proteae, Hydrolase
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3.4.22.38 ExPASy BRENDA (A)
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Homo sapiens(human) 9606(A)
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Cathepsin K precursor (EC 3.4.22.38) (Cathepsin O) (Cathepsin X) (Cathepsin O2) P43235 (A)
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A
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| A |
Cathepsin K |
Protein |
P43235 (CATK_HUMAN)
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215 |
100% |
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| A |
N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE |
NFT
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