1vr2 Summary

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HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (KDR) KINASE DOMAIN

The structure was published by McTigue, M.A., Wickersham, J.A., Pinko, C., et al., Kan, C.C., Villafranca, J.E., and Appelt, K., in 1999 in a paper entitled "Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KINASE). This molecule has the UniProt identifier P35968 (VGFR2_HUMAN)search. The sample contained 316 residues which is < 90% of the natural sequence. Out of 316 residues 269 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KINASE) P35968 (806-1171) (VGFR2_HUMAN)search Homo sapienssearch < 90% 316 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35968 (806 - 1171) PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KINASE) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35968) protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch ATP bindingsearch protein kinase activitysearch growth factor bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transmembrane receptor protein tyrosine kinase activitysearch vascular endothelial growth factor-activated receptor activitysearch integral component of membranesearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Vascular endothelial growth factor receptor 2 (VEGFR2)search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch