1vid Summary

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CATECHOL O-METHYLTRANSFERASE

The structure was published by Vidgren, J., Svensson, L.A., and Liljas, A., in 1994 in a paper entitled "Crystal structure of catechol O-methyltransferase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CATECHOL O-METHYLTRANSFERASE. This molecule has the UniProt identifier P22734 (COMT_RAT)search. The sample contained 221 residues which is < 90% of the natural sequence. Out of 221 residues 213 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CATECHOL O-METHYLTRANSFERASE P22734 (44-264) (COMT_RAT)search Rattus norvegicussearch < 90% 221 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22734 (44 - 264) CATECHOL O-METHYLTRANSFERASE Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A COMT-likesearch Vaccinia Virus protein VP39search O-methyltransferasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P22734) magnesium ion bindingsearch catechol O-methyltransferase activitysearch O-methyltransferase activitysearch catecholamine metabolic processsearch neurotransmitter catabolic processsearch

Chain InterPro annotation
A O-methyltransferase, family 3search Catechol O-methyltransferase, eukaryoticsearch Catechol O-methyltransferasesearch S-adenosyl-L-methionine-dependent methyltransferase-likesearch