1vft Summary


Crystal structure of L-cycloserine-bound form of alanine racemase from D-cycloserine-producing Streptomyces lavendulae

The structure was published by Noda, M., Matoba, Y., Kumagai, T., and Sugiyama, M., in 2004 in a paper entitled "Structural evidence that alanine racemase from a D-cycloserine-producing microorganism exhibits resistance to its own product." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2004.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of alanine racemase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A alanine racemase Q65YW7 (1-378) (Q65YW7_STRLA)search Streptomyces lavendulae subsp. lavendulaesearch 100% 386 98%
B alanine racemase Q65YW7 (1-378) (Q65YW7_STRLA)search Streptomyces lavendulae subsp. lavendulaesearch 100% 386 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q65YW7 (1 - 378) alanine racemase Streptomyces lavendulae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q65YW7) Alanine racemase-like, N-terminal domainsearch, Alanine racemasesearch Lyase, Ornithine Decarboxylase; Chain A, domain 1search, Alanine racemasesearch PF00842: Alanine racemase, C-terminal domainsearch, PF01168: Alanine racemase, N-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (Q65YW7) D-alanine biosynthetic processsearch alanine metabolic processsearch alanine racemase activitysearch catalytic activitysearch pyridoxal phosphate bindingsearch isomerase activitysearch

Chain InterPro annotation
A, B Alanine racemasesearch Alanine racemase, N-terminalsearch Alanine racemase/group IV decarboxylase, C-terminalsearch Alanine racemase, C-terminalsearch Alanine racemase, pyridoxal-phosphate attachment sitesearch PLP-binding barrelsearch