1vbt Summary

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Structure of cyclophilin complexed with sulfur-substituted tetrapeptide AAPF

A publication describing this structure is not available. The depositing authors are Zhao, Y.search; Chen, Y.search; Schutkowski, M.search; Fischer, G.search; Ke, H.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CYCLOPHILIN A and SULFUR-SUBSTITUTED TETRAPEPTIDE.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOPHILIN A P62937 (1-165) (PPIA_HUMAN)search Homo sapienssearch 99% 165 99%
B CYCLOPHILIN A P62937 (1-165) (PPIA_HUMAN)search Homo sapienssearch 99% 165 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62937 (1 - 165) CYCLOPHILIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P62937) Cyclophilin (peptidylprolyl isomerase)search Cyclophilinsearch PF00160: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P62937) protein peptidyl-prolyl isomerizationsearch protein foldingsearch platelet activationsearch viral release from host cellsearch viral life cyclesearch virion assemblysearch entry into host cellsearch establishment of integrated proviral latencysearch viral processsearch positive regulation of viral genome replicationsearch uncoating of virussearch RNA-dependent DNA replicationsearch positive regulation of protein secretionsearch lipid particle organizationsearch platelet degranulationsearch blood coagulationsearch leukocyte migrationsearch regulation of viral genome replicationsearch peptidyl-prolyl cis-trans isomerase activitysearch isomerase activitysearch unfolded protein bindingsearch poly(A) RNA bindingsearch protein bindingsearch virion bindingsearch peptide bindingsearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch nucleussearch cytoplasmsearch membranesearch focal adhesionsearch extracellular spacesearch

Chain InterPro annotation
A, B Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainsearch Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved sitesearch Cyclophilin-type peptidyl-prolyl cis-trans isomerasesearch Cyclophilin-like domainsearch