1vas Summary

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ATOMIC MODEL OF A PYRIMIDINE DIMER SPECIFIC EXCISION REPAIR ENZYME COMPLEXED WITH A DNA SUBSTRATE: STRUCTURAL BASIS FOR DAMAGED DNA RECOGNITION

The structure was published by Vassylyev, D.G., Kashiwagi, T., Mikami, Y., et al., Iwai, S., Ohtsuka, E., and Morikawa, K., in 1995 in a paper entitled "Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: structural basis for damaged DNA recognition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 1995.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*AP*TP*CP*GP*CP*GP*TP*TP*GP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*CP*AP*AP*CP*GP*CP*GP*A)-3'), and PROTEIN (T4 ENDONUCLEASE V (E.C.3.1.25.1)).

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (T4 ENDONUCLEASE V (E.C.3.1.25.1)) P04418 (2-138) (END5_BPT4)search Enterobacteria phage T4search 99% 137 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04418 (2 - 138) PROTEIN (T4 ENDONUCLEASE V (E.C.3.1.25.1)) Enterobacteria phage T4

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P04418) T4 endonuclease Vsearch Endonuclease Vsearch PF03013: Pyrimidine dimer DNA glycosylasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P04418) hydrolase activitysearch deoxyribonuclease (pyrimidine dimer) activitysearch hydrolase activity, acting on glycosyl bondssearch nuclease activitysearch endonuclease activitysearch DNA repairsearch cellular response to DNA damage stimulussearch nucleic acid phosphodiester bond hydrolysissearch metabolic processsearch DNA catabolic process, endonucleolyticsearch

Chain InterPro annotation
A Pyrimidine dimer DNA glycosylasesearch Pyrimidine dimer DNA glycosylase, endonuclease V typesearch T4 endonuclease Vsearch