1v4t Summary


Crystal structure of human glucokinase

The structure was published by Kamata, K., Mitsuya, M., Nishimura, T., Eiki, J., and Nagata, Y., in 2004 in a paper entitled "Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.4 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of glucokinase isoform 2. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 451 residues which is 97% of the natural sequence. Out of 451 residues 424 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A glucokinase isoform 2 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 451 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) glucokinase isoform 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P35557) Hexokinasesearch Hexokinase; domain 1search, Nucleotidyltransferase; domain 5search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35557) ATP bindingsearch phosphotransferase activity, alcohol group as acceptorsearch protein bindingsearch transferase activitysearch glucose bindingsearch glucokinase activitysearch hexokinase activitysearch fructokinase activitysearch magnesium ion bindingsearch ADP bindingsearch nucleotide bindingsearch kinase activitysearch catalytic activitysearch protein phosphatase bindingsearch mannokinase activitysearch carbohydrate metabolic processsearch glycolytic processsearch metabolic processsearch glucose transportsearch cellular response to leptin stimulussearch regulation of insulin secretionsearch glycogen biosynthetic processsearch regulation of potassium ion transportsearch carbohydrate phosphorylationsearch negative regulation of epinephrine secretionsearch glucose metabolic processsearch positive regulation of insulin secretionsearch NADP metabolic processsearch cellular glucose homeostasissearch hexose transportsearch cellular response to insulin stimulussearch regulation of glucose transportsearch positive regulation of cytosolic calcium ion concentrationsearch transmembrane transportsearch cellular response to glucose starvationsearch endocrine pancreas developmentsearch glucose homeostasissearch calcium ion importsearch regulation of glycolytic processsearch positive regulation of glycolytic processsearch detection of glucosesearch second-messenger-mediated signalingsearch positive regulation of phosphorylationsearch fructose 2,6-bisphosphate metabolic processsearch response to glucosesearch phosphorylationsearch negative regulation of gluconeogenesissearch positive regulation of glycogen biosynthetic processsearch glucose 6-phosphate metabolic processsearch small molecule metabolic processsearch cytosolsearch nucleussearch cytoplasmsearch nucleoplasmsearch mitochondrionsearch secretory granulesearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch