1v4s Summary


Crystal structure of human glucokinase

The structure was published by Kamata, K., Mitsuya, M., Nishimura, T., Eiki, J., and Nagata, Y., in 2004 in a paper entitled "Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of glucokinase isoform 2. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 455 residues which is 97% of the natural sequence. Out of 455 residues 448 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A glucokinase isoform 2 P35557 (16-465) (HXK4_HUMAN)search Homo sapienssearch 97% 455 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (16 - 465) glucokinase isoform 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P35557) Hexokinasesearch Hexokinase; domain 1search, Nucleotidyltransferase; domain 5search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P35557) ATP bindingsearch protein bindingsearch ADP bindingsearch glucose bindingsearch magnesium ion bindingsearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch transferase activitysearch kinase activitysearch glucokinase activitysearch protein phosphatase bindingsearch mannokinase activitysearch nucleotide bindingsearch catalytic activitysearch fructokinase activitysearch glucose homeostasissearch endocrine pancreas developmentsearch glucose metabolic processsearch transmembrane transportsearch response to glucosesearch positive regulation of cytosolic calcium ion concentrationsearch regulation of insulin secretionsearch glycogen biosynthetic processsearch fructose 2,6-bisphosphate metabolic processsearch phosphorylationsearch small molecule metabolic processsearch cellular glucose homeostasissearch glycolytic processsearch second-messenger-mediated signalingsearch positive regulation of phosphorylationsearch hexose transportsearch cellular response to insulin stimulussearch carbohydrate metabolic processsearch regulation of glucose transportsearch cellular response to leptin stimulussearch NADP metabolic processsearch detection of glucosesearch regulation of glycolytic processsearch carbohydrate phosphorylationsearch positive regulation of glycogen biosynthetic processsearch positive regulation of insulin secretionsearch cellular response to glucose starvationsearch negative regulation of epinephrine secretionsearch glucose transportsearch positive regulation of glycolytic processsearch calcium ion importsearch negative regulation of gluconeogenesissearch metabolic processsearch glucose 6-phosphate metabolic processsearch regulation of potassium ion transportsearch nucleoplasmsearch nucleussearch cytosolsearch secretory granulesearch cytoplasmsearch cell cortexsearch mitochondrionsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch