1v25 Summary


Crystal structure of tt0168 from Thermus thermophilus HB8

The structure was published by Hisanaga, Y., Ago, H., Nakagawa, N., et al., Kuramitsu, S., Yokoyama, S., and Miyano, M., in 2004 in a paper entitled "Structural Basis of the Substrate-specific Two-step Catalysis of Long Chain Fatty Acyl-CoA Synthetase Dimer" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of long-chain-fatty-acid-CoA synthetase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A long-chain-fatty-acid-CoA synthetase Q5SKN9 (1-541) (LCFCS_THET8)search Thermus thermophilus HB8search 100% 541 93%
B long-chain-fatty-acid-CoA synthetase Q5SKN9 (1-541) (LCFCS_THET8)search Thermus thermophilus HB8search 100% 541 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q5SKN9 (1 - 541) long-chain-fatty-acid-CoA synthetase Thermus thermophilus

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B (Q5SKN9) Acetyl-CoA synthetase-likesearch PF00501: AMP-binding enzymesearch, PF13193: AMP-binding enzyme C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q5SKN9) catalytic activitysearch long-chain fatty acid-CoA ligase activitysearch ATP bindingsearch metal ion bindingsearch nucleotide bindingsearch ligase activitysearch fatty acid metabolic processsearch metabolic processsearch lipid metabolic processsearch long-chain fatty acid metabolic processsearch

Chain InterPro annotation
A, B AMP-dependent synthetase/ligasesearch AMP-binding, conserved sitesearch AMP-binding enzyme C-terminal domainsearch