1v1k Summary


PDB entry 1v1k (supersedes 1h06)


The structure was published by Beattie, J.F., Breault, G.A., Ellston, R.P.A., et al., Pauptit, R.A., Tucker, J.A., and Pease, J.E., in 2003 in a paper entitled "Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.31 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P24941) protein phosphorylationsearch cell divisionsearch cell cyclesearch mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch mitosissearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch Ras protein signal transductionsearch phosphorylationsearch G2/M transition of mitotic cell cyclesearch DNA replicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic G1 DNA damage checkpointsearch meiosissearch positive regulation of transcription, DNA-dependentsearch positive regulation of cell proliferationsearch response to DNA damage stimulussearch potassium ion transportsearch regulation of gene silencingsearch blood coagulationsearch histone phosphorylationsearch G1/S transition of mitotic cell cyclesearch DNA repairsearch centrosome duplicationsearch mitotic G2 phasesearch cellular response to nitric oxidesearch condensed chromosomesearch nucleoplasmsearch cytoplasmsearch cytoskeletonsearch nucleussearch cytosolsearch endosomesearch Y chromosomesearch Cajal bodysearch chromosome, telomeric regionsearch microtubule organizing centersearch cyclin-dependent protein kinase holoenzyme complexsearch transcription factor complexsearch X chromosomesearch centrosomesearch protein bindingsearch histone kinase activitysearch protein kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch transferase activitysearch metal ion bindingsearch cyclin bindingsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch