1v18 Summary

pdbe.org/1v18
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THE CRYSTAL STRUCTURE OF BETA-CATENIN ARMADILLO REPEAT COMPLEXED WITH A PHOSPHORYLATED APC 20MER REPEAT.

The structure was published by Ha, N.-C., Tonozuka, T., Stamos, J.L., and Weis, W.I., in 2004 in a paper entitled "Mechanism of Phosphorylation-Dependent Binding of Apc to Beta-Catenin and its Role in Beta-Catenin Degradation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely BETA-CATENIN and ADENOMATOUS POLYPOSIS COLI.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BETA-CATENIN Q02248 (134-671) (CTNB1_MOUSE)search Mus musculussearch < 90% 538 94%
B ADENOMATOUS POLYPOSIS COLI P25054 (1482-1528) (APC_HUMAN)search Homo sapienssearch < 90% 47 85%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q02248 (134 - 671) BETA-CATENIN Mus musculus
P25054 (1482 - 1528) ADENOMATOUS POLYPOSIS COLI Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Armadillo repeatsearch Leucine-rich Repeat Variantsearch Armadillo/beta-catenin-like repeatsearch
B APC cysteine-rich regionsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
B (P25054) beta-catenin bindingsearch positive regulation of apoptotic processsearch cell cycle arrestsearch cell migrationsearch cellular response to DNA damage stimulussearch negative regulation of cell proliferationsearch negative regulation of Wnt signaling pathwaysearch mitotic cytokinesissearch negative regulation of microtubule depolymerizationsearch Wnt signaling pathwaysearch nucleussearch cytoplasmsearch

Chain InterPro annotation
A Armadillosearch Armadillo-like helicalsearch Beta-cateninsearch Armadillo-type foldsearch
B Adenomatous polyposis coli protein, cysteine-rich repeatsearch Adenomatous polyposis coli (APC) familysearch Adenomatous polyposis colisearch