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PDBe Entry: 1v11 
CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE
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OXIDOREDUCTASE
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X-RAY DIFFRACTION
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Resolution: 1.95 Å, R-factor: 13.9%, Free R-factor: 17.1%, Spacegroup: P 31 2 1
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03/06/2004, deposition: 05/04/2004, last revision: 24/02/2009
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Li, J.; Wynn, R.M.; Machius, M.; Chuang, J.L.; Karthikeyan, S.; Tomchick, D.R.; Chuang, D.T.
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Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain {Alpha}-Keto Acid Decarboxylase/Dehydrogenase
J.BIOL.CHEM. vol:279, pag:32968 (2004) [PubMed ID 15166214 ]
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OXIDOREDUCTASE, KETOACID DEHYDROGENASE, BRANCHED-CHAIN, MULTI-ENZYME COMPLEX, ACYLATION, OXIDATIVE DECARBOXYLATION, MAPLE SYRUP URINE DISEASE, THIAMINE PHOSPHATE, PHOSPHORYLATION
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1.2.4.4 ExPASy BRENDA (A B)
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Homo sapiens(human) 9606(A B)
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2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDH E1-alpha) (BCKDE1A) P12694 (A)
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial precursor (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta) P21953 (B)
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A, B
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1dtw, 1ols, 1olu, 1olx, 1v16, 1v1m, 1v1r
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| A |
2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT |
Protein |
P12694 (ODBA_HUMAN)
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400 |
92% |
| B |
2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT |
Protein |
P21953 (ODBB_HUMAN)
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342 |
98% |
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| A, B |
POTASSIUM ION |
K
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| A |
MANGANESE (II) ION |
MN
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| A |
CHLORIDE ION |
CL
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| A |
THIAMIN DIPHOSPHATE |
TDP
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| A |
BENZAMIDINE |
BEN
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| B |
GLYCEROL |
GOL
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