1v0b Summary

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CRYSTAL STRUCTURE OF THE T198A MUTANT OF PFPK5

The structure was published by Holton, S., Merckx, A., Burgess, D., Doerig, C., Noble, M., and Endicott, J., in 2003 in a paper entitled "Structures of P. Falciparum Pfpk5 Test the Cdk Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CELL DIVISION CONTROL PROTEIN 2 HOMOLOG.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION CONTROL PROTEIN 2 HOMOLOG Q07785 (1-288) (CDC2H_PLAFK)search Plasmodium falciparum K1search 100% 288 99%
B CELL DIVISION CONTROL PROTEIN 2 HOMOLOG Q07785 (1-288) (CDC2H_PLAFK)search Plasmodium falciparum K1search 100% 288 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q07785 (1 - 288) CELL DIVISION CONTROL PROTEIN 2 HOMOLOG Plasmodium falciparum

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q07785) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q07785) protein phosphorylationsearch phosphorylationsearch regulation of cell cyclesearch cyclin-dependent protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch nucleotide bindingsearch transferase activitysearch kinase activitysearch RNA polymerase II carboxy-terminal domain kinase activitysearch cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch