1uwh Summary


The complex of wild type B-RAF and BAY439006

The structure was published by Wan, P.T.C., Garnett, M.J., Roe, S.M., et al., Springer, C.J., Barford, D., and Marais, R., in 2004 in a paper entitled "Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.95 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE P15056 (448-723) (BRAF_HUMAN)search Homo sapienssearch < 90% 276 95%
B B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE P15056 (448-723) (BRAF_HUMAN)search Homo sapienssearch < 90% 276 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P15056) protein phosphorylationsearch regulation of signal transductionsearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch