› 1uw3

X-ray diffraction
2.05Å resolution

The crystal structure of the globular domain of sheep prion protein

Released:
DOI: 10.2210/pdb1uw3/pdb
PDB entry 1uw3 coloured by chain, front view.
PDB entry 1uw3 coloured by chain, side view.
PDB entry 1uw3 coloured by chain, top view.
Source organism: Ovis aries
Primary publication:
The crystal structure of the globular domain of sheep prion protein.
Haire LF, Whyte SM, Vasisht N, Gill AC, Verma C, Dodson EJ, Dodson GG, Bayley PM
J Mol Biol 336 1175-83 (2004)
PMID: 15037077

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150113 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chain: A
Molecule details ›
Chain: A
Length: 106 amino acids
Theoretical weight: 12.61 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P23907 (Residues: 128-233; Coverage: 46%)
Gene names: PRNP, PRP, SIP
Sequence domains: Prion/Doppel alpha-helical domain
Structure domains: Prion/Doppel protein, beta-ribbon domain

Ligands and Environments

2 bound ligands:
Ligand GSH 1 x GSH
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21212
Unit cell:
a: 85.068Å b: 29.045Å c: 45.896Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.222 0.33

Quick links

Citations

16 review citations

Copper and the prion protein: methods, structures, function, and disease.
Millhauser GL. (2007)
15 more

15 mentions without citation

A structural overview of the vertebrate prion proteins.
Pastore et al. (2007)
14 more