1uvq Summary

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CRYSTAL STRUCTURE OF HLA-DQ0602 IN COMPLEX WITH A HYPOCRETIN PEPTIDE

The structure was published by Siebold, C., Hansen, B.E., Wyer, J.R., et al., Strominger, J.L., Jones, E.Y., and Fugger, L., in 2004 in a paper entitled "Crystal Structure of Hla-Dq0602 that Protects Against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely HLA CLASS II HISTOCOMPATIBILITY ANTIGEN and OREXIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA CLASS II HISTOCOMPATIBILITY ANTIGEN P01909 (24-78) (DQA1_HUMAN)search ,
P01909 (79-218) (DQA1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
197 92%
B HLA CLASS II HISTOCOMPATIBILITY ANTIGEN P01920 (35-230) (DQB1_HUMAN)search Homo sapienssearch < 90% 198 91%
C OREXIN O43612 (1-12) (OREX_HUMAN)search Homo sapienssearch < 90% 33 60%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01909 (24 - 78) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN Homo sapiens
P01920 (35 - 230) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN
O43612 (1 - 12) OREXIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A MHC antigen-recognition domainsearch, C1 set domains (antibody constant domain-like)search Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C Prepro-orexinsearch

Chain ID Cellular component (GO) Biological process (GO)
A (P01909) membranesearch MHC class II protein complexsearch antigen processing and presentationsearch immune responsesearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C