1uu3 Summary

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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531

The structure was published by Komander, D., Kular, G.S., Schuttelkopf, A.W., et al., Kozikowski, A.P., Alessi, D.R., and Van Aalten, D.M.F., in 2004 in a paper entitled "Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1. This molecule has the UniProt identifier O15530 (PDPK1_HUMAN)search. The sample contained 310 residues which is < 90% of the natural sequence. Out of 310 residues 274 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1 O15530 (51-360) (PDPK1_HUMAN)search Homo sapienssearch < 90% 310 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O15530 (51 - 360) 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (O15530) protein phosphorylationsearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch