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NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE: EVIDENCE FOR A SECOND SIALIC ACID BINDING SITE AND IMPLICATIONS FOR FUSION

The structure was published by Zaitsev, V., Von Itzstein, M., Groves, D., et al., Takimoto, T., Portner, A., and Taylor, G., in 2004 in a paper entitled "Second Sialic Acid Binding Site in Newcastle Disease Virus Hemagglutinin-Neuraminidase: Implications for Fusion" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2003.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN P32884 (124-577) (HN_NDVB)search Newcastle disease virus strain Beaudette C/45search < 90% 454 98%
B HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN P32884 (124-577) (HN_NDVB)search Newcastle disease virus strain Beaudette C/45search < 90% 454 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P32884 (124 - 577) HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN Newcastle disease virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Sialidases (neuraminidases)search Neuraminidasesearch Haemagglutinin-neuraminidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P32884) viral life cyclesearch viral envelopesearch host cell surface receptor bindingsearch exo-alpha-sialidase activitysearch

Chain InterPro annotation
A, B Haemagglutinin-neuraminidasesearch Sialidasessearch