1urz Summary

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LOW PH INDUCED, MEMBRANE FUSION CONFORMATION OF THE ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS

The structure was published by Bressanelli, S., Stiasny, K., Allison, S.L., et al., Lescar, J., Heinz, F.X., and Rey, F.A., in 2004 in a paper entitled "Structure of a Flavivirus Envelope Glycoprotein in its Low-Ph-Induced Membrane Fusion Conformation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of ENVELOPE PROTEIN.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ENVELOPE PROTEIN Q80E47 (196-596) (Q80E47_9FLAV)search Tick-borne encephalitis virussearch < 90% 401 96%
B ENVELOPE PROTEIN Q80E47 (196-596) (Q80E47_9FLAV)search Tick-borne encephalitis virussearch < 90% 401 96%
C ENVELOPE PROTEIN Q80E47 (196-596) (Q80E47_9FLAV)search Tick-borne encephalitis virussearch < 90% 401 96%
D ENVELOPE PROTEIN Q80E47 (196-596) (Q80E47_9FLAV)search Tick-borne encephalitis virussearch < 90% 401 96%
E ENVELOPE PROTEIN Q80E47 (196-596) (Q80E47_9FLAV)search Tick-borne encephalitis virussearch < 90% 401 96%
F ENVELOPE PROTEIN Q80E47 (196-596) (Q80E47_9FLAV)search Tick-borne encephalitis virussearch < 90% 401 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q80E47 (196 - 596) ENVELOPE PROTEIN Tick-borne encephalitis virus (WESTERN SUBTYPE)

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F Class II viral fusion proteins C-terminal domainsearch, Viral glycoprotein, central and dimerisation domainssearch Tick-borne Encephalitis virus Glycoprotein, domain 1search, Viral Envelope Glycoprotein, domain 2search, Viral Envelope Glycoprotein, domain 3search, Immunoglobulin-likesearch Flavivirus glycoprotein, central and dimerisation domainssearch, Flavivirus glycoprotein, immunoglobulin-like domainsearch

Chain ID Molecular function (GO) Cellular component (GO)
A, B, C, D, E, F (Q80E47) protein dimerization activitysearch viral envelopesearch integral component of membranesearch

Chain InterPro annotation
A, B, C, D, E, F Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domainsearch Flavivirus glycoprotein central and dimerisation domainsearch Glycoprotein E dimerisation domainsearch Flaviviral glycoprotein, central domain, subdomain 1search Glycoprotein E central domain, subdomain 2search Immunoglobulin E-setsearch Flavivirus glycoprotein, immunoglobulin-like domainsearch