1uro Summary

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UROPORPHYRINOGEN DECARBOXYLASE

The structure was published by Whitby, F.G., Phillips, J.D., Kushner, J.P., and Hill, C.P., in 1998 in a paper entitled "Crystal structure of human uroporphyrinogen decarboxylase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PROTEIN (UROPORPHYRINOGEN DECARBOXYLASE). This molecule has the UniProt identifier P06132 (DCUP_HUMAN)search. The sample contained 367 residues which is 100% of the natural sequence. Out of 367 residues 357 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (UROPORPHYRINOGEN DECARBOXYLASE) P06132 (1-367) (DCUP_HUMAN)search Homo sapienssearch 97% 367 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06132 (1 - 367) PROTEIN (UROPORPHYRINOGEN DECARBOXYLASE) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P06132) Uroporphyrinogen decarboxylase, URODsearch TIM Barrelsearch PF01208: Uroporphyrinogen decarboxylase (URO-D)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P06132) heme biosynthetic processsearch protoporphyrinogen IX biosynthetic processsearch small molecule metabolic processsearch porphyrin-containing compound biosynthetic processsearch porphyrin-containing compound metabolic processsearch heme metabolic processsearch uroporphyrinogen decarboxylase activitysearch lyase activitysearch carboxy-lyase activitysearch cytosolsearch cytoplasmsearch

Chain InterPro annotation
A Uroporphyrinogen decarboxylase (URO-D)search Uroporphyrinogen decarboxylase HemEsearch